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Applexion Short Course Spring 2024

Technical Short Course: Theory & Application

Presented By: Applexion

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About the Course

Dates: April 23-25, 2024

Cost: $700/day

Agenda:

APPLEXION Technical Short Course Day #1

Tuesday April 23, 2024

Chromatography Technology & Applications

The AM session will focus on the basic theory behind the technology, including common terms and definitions, evolution of industrial chromatography, basic flow process, physico-chemical interactions, how separation occurs, modes of operation, resin selection, and how to size a system. The PM session will focus on the implementation of this technology in industrial plants, including pilot testing, scaling-up, installation/commissioning/operation of a system, as well as typical maintenance and troubleshooting guidelines. It will also include new digital tools presentation for day-to-day operational optimization and digital platforms demonstration (dashboards, data management, etc.).

Speakers:

Hector Osuna

PhD R&D Manager, Chromatography Process Expert

Antoine Charbonneau

Process & Sales Manager, American Team

PART 1 – 9AM to 10:30AM

  • Introduction to Chromatography.
  • Deep journey into the theory: chemical & physical interactions, main equations & design implications.

Morning break

PART 2 – 10:45AM to 12PM

  • Scale-Up: from lab to industrial scale (defining CAPEX and OPEX from trials).
  • Batch Chromatography to Continuous Chromatography.

LUNCH TIME 12PM-1PM

PM SESSION

PART 1 – 1PM to 3:00PM

  • Industrial Design: Process design & industrial equipment.
  • System Operation: Separation zones, parameters setting, operation sequences, troubleshooting guidelines.
  • Case studies: Sugars & Sweeteners, Organic Acids.

Afternoon break

PART 2 – 3:15PM to 4:45PM

  • Digital Tools: Run4.0 & Perform4.0, Link4.0.
  • Run4.0 & Perform4.0 digital platforms Demo.

Evening Reception at  Triptych Brewing

 

APPLEXION Technical Short Course Day #2

Wednesday April 24th, 2024

Ion Exchange Technology & Applications

The AM session will focus on the basic theory behind the technology, including common terms and definitions, evolution of industrial ion exchange, basic flow process, physico-chemical interactions, how purification occurs, modes of operation, resin selection, and how to size a system. The PM session will focus on the implementation of this technology in industrial plants, including pilot testing, scaling-up, installation/commissioning/operation of a system, as well as typical maintenance and troubleshooting guidelines. It will also include typical case studies review.

Speakers:

Hector Osuna

PhD R&D Manager, Chromatography Process Expert

 

Antoine Charbonneau

Process & Sales Manager, American Team

AM SESSION

PART 1 – 9AM to 10:30AM

  • Introduction to Ion Exchange.
  • Deep journey into the theory: chemical & physical interactions, design implications.

Morning break

PART 2 – 10:45AM to 12PM

  • Scale-Up: from lab to industrial scale (defining CAPEX and OPEX from trials).
  • Ion Exchange Resin Types & Applications.

LUNCH TIME 12PM-1PM

PM SESSION

PART 1 – 1PM to 2:30PM

  • Industrial Design: Process design & industrial equipment.
  • System Operation: Pressure vessels improvements, recycling, troubleshooting guidelines.

Afternoon break

PART 2 – 2:45PM to 3:45PM – Case studies: Sugars & Sweeteners, Amino Acids, Proteins.

3:45PM-4:45PM- IBRL Pilot Plant Tour

 

APPLEXION Technical Short Course Day #3

Membrane Filtration Technology & Applications

Thursday April 25th, 2024

The AM session will focus on the basic theory behind the technology, including common terms and definitions, brief history of ceramic membranes, basic flow process, physico-chemical interactions, how separation occurs, modes of operation, pore size selection, how to size a system, as well as on pilot testing and scaling-up through case study.
The PM session will focus on the implementation of this technology in industrial plants, installation/commissioning/operation of system, equipment and controls, typical maintenance and troubleshooting guidelines, as well as on polymeric membrane and Complete Process Line case study. It will also include a ceramic membrane filtration pilot demonstration.

Speaker:

Hafedh Saidani

PhD CPL Manager, Membrane Process Expert

AM SESSION

PART 1 – 9AM to 10:30AM

  • Membrane Terms and Definitions.
  • Ceramic Membranes: Manufacturing, properties, strengths & weaknesses, geometries, pore sizes & configurations.
  • Membrane Filtration Process & System: Terms & definitions (Recovery, VCF, diafiltration, etc.), assembly, configurations, batch, fed-batch, etc.

Morning break

PART 2 – 10:45AM to 12PM

  • Ceramic Membrane Selection: Pore size & geometry.
  • Case Study: Scaling-Up from pilot testing to the industrial plant.

LUNCH TIME – 12PM to 1PM

PM SESSION

PART 1 – 1PM to 2:15PM

  • Equipment & Control: Process control, CIP, backpulse, utility recovery, etc.
  • Troubleshooting guidelines.

Afternoon break

PART 2 – 2:30PM to 4PM

  • Polymeric membrane (UF, NF).
  • Case Study: Industrial Membrane system and Complete Process Line.

4:00-4:45PM- Pilot Plant Demo: Run & Perform K01

5:00PM-5:15PM- Certificates and Group Photo

About the Speakers:

Hector Osuna

PhD R&D Manager, Chromatography Process Expert

Hector is a chemical engineer with expertise in process modeling, reaction engineering and separation science. He graduated from CPE Lyon Engineering School (Lyon, France) with major in chemical engineering and obtained his Ph.D. from the University of Lyon (UCB Lyon1, France). He worked at Novasep as an expert on modeling and simulation of chromatographic processes for pharma, biopharma and industrial biotech. He contributed at lab-scale and proof-of-concept of innovative multicolumn processes. He also held positions as Innovation Team Manager at Processium, combining chemical engineering and numerical tools, and as Head of Biotech Modeling at Ypso-Facto, working on the development of simulation software solutions for chromatographic processes and its application for assisting industrial companies. He joined back Novasep in 2020 as R&D and Pilot Manager, heading a 10-people team with lab and pilot capabilities coupled with numerical tools for efficient development of industrial processes and scale-up derisking into Novasep systems.

 

Antoine Charbonneau

Process & Sales Manager, American Team

Antoine Charbonneau is Process & Sales Manager for the American team, based in Denver, CO. He has been working for Applexion over the Americas region for more than 7 years, specializing in various markets including Food, Functional ingredient and Bio industries (Fermentation) activities. Prior to that, he worked for several years as Process Engineer in Shanghai, China where he designed and engineered number of projects in the field of biotech and food & beverage, either for complete turnkey plants, or specific purification process units. He also published scientific articles in international reviews such as the Sugar Journal and participated to number of R&D developments, some of which having been patented. Antoine is current and former member of Sugar Industry Technologists, American Society of Sugar Cane Technologists, and American Dairy Product Institute. He holds a position as a board member in several technical sub commitees of these associations.

Hafedh Saidani

PhD CPL Manager, Membrane Process Expert

Hafedh is a chemical engineer with 20 years’ experience in membrane science and technology. He graduated from INSA (Tunisia) with major in industrial chemistry engineering and obtained his Ph.D. in process science from the University of Montpellier (European Institute of membrane, France). He worked as R&D engineer at CNRS, he focused on experimentation, modeling and simulation of Nanofiltration process technlology. He also held positions as test center manager at IFTS (International Filter testing Services) for testing and qualification of purification equipment for wide variety of industries including the water, chemical, biotechnologies and nuclear industries. heading a 8-people team with pilot purification capabilities. He joined Applexion on 2017 as process expert on membrane technology: a transversal position for both scientific and industrial expertise: He support several department : R&D, sales, process as well as our customers around the world for the plant commissioning or  trouble shooting issues. Since 2022 he had a new position at Applexion as process line manager, heading concept design and Sales of robust Process Lines that complement Applexion proprietary technologies, with Partners technologies.

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General Information

Contacts:

Amy Rogers arogers9@illinois.edu

Kerri Peters kerrip@illinois.edu

Location: The Integrated Bioprocessing Research Laboratory 1300 W. Pennsylvania Ave Urbana, IL 61801

Meals: Light Breakfast and Lunches will be provided. There is an optional evening reception on Tuesday, food and beverages will be provided.

Hotel: IBRL has reserved a block of hotel rooms at the iHotel (https://go.illinois.edu/iHotel), which are available on a first come, first serve basis. Shuttle transportation will be provided to and from the I-Hotel and the course events. To make your reservation, please go to https://go.illinois.edu/booking and use Block Code: IBRLAPRIL24 and password: 8Uz*V You may also call the I-Hotel directly at 217-819-500 and mention the hotel Block Code IBRLAPRIL24.

If you are flying into Willard Airport, the I-Hotel offers a shittle on an as needed basis. To schedule a shuttle, please call the I-Hotel directly at 217-819-5000 to make arrangements.

Transportation: A shuttle will be provided between the hotel and course location. The shuttle will also transport participants to and from the Tuesday evening reception.